Transdermal and transmucosal absorption of drugs. Overview.
نویسندگان
چکیده
منابع مشابه
Noninvasive Transdermal and Transmucosal Drug Delivery Technologies
Overcoming the barrier function of the skin already poses a great challenge to modern drug delivery systems, but no less important are safety and tolerability aspects. In the past, many common drug penetration enhancement strategies turned out to destroy the natural barrier function of the skin and cause irritations and other partially severe side-effects. Therefore, right from the beginning MI...
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The permeability characteristics of newborn pig skin and adult rat skin, either fresh or stored, to model drugs were examined and compared. Special attention was paid to the design to a new experimental system suitable for evaluation of skin permeability to various substances. Two types of model substances were used; insulin, a poorly absorbable substance with high molecular weight as a represe...
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With the current high level of interest in patches to deliver drugs across the skin, the concept of external applications for delivery of medicinal substances is becoming widely accepted. This study evaluated the potential for transdermal absorption of castor oil, a treatment modality recommended by Edgar Cayce. Specific epoxydicarboxylic acids are known to be excreted via the urine when castor...
متن کاملTransdermal Delivery of Drugs with Microneedles—Potential and Challenges
Transdermal drug delivery offers a number of advantages including improved patient compliance, sustained release, avoidance of gastric irritation, as well as elimination of pre-systemic first-pass effect. However, only few medications can be delivered through the transdermal route in therapeutic amounts. Microneedles can be used to enhance transdermal drug delivery. In this review, different ty...
متن کاملPravastatin transdermal patch: Effect of the formulation and length of microneedles on in- vitro percutaneous absorption studies.
Transdermal patches loaded with pravastatin was previously characterized in another published study by Serrano-Castañeda et al; 2015. These transdermal patches (TP) were generated by the plate casting technique, the in vitro percutaneous absorption studies of TP were evaluated for three different formulations of TP with different quantities of Pluronic F-127 (PF-127): i) without PF-127 (TP W), ...
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2000
ISSN: 1881-2732,0913-5006
DOI: 10.2745/dds.15.492